The Astana Times

Kazakh Teen Engineer Designs Robot That Solves Rubik’s Cube in 60 Seconds

ALMATY — Shakhnazar Kamalov, a seventh-grade student from Astana, has built a smart robot capable of cracking a Rubik’s Cube ...

Bringing AI into the NICU: How algorithms may help infants' eyes, health

When ophthalmologist Emily Cole, MD, steps into the neonatal intensive care unit (NICU) at Children's Hospital Colorado to ...
Nature

Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations

Enzymatic ligation methods are useful in diagnostic detection of DNA sequences. Here we describe the investigation of nonenzymatic phosphorothioate–iodide DNA autoligation chemistry as a method for ...
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...
eLife

TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...
Nature

Multiplex PCR by multicolor fluorimetry and fluorescence melting curve analysis

Figure 1: Probe orientation, spectral overlap and color compensation for multicolor Nras mutation detection. Serial dilutions were performed using DNA extracted from Nras mutation-bearing cell lines ...